Learning Module Overview for:
Current Treatment of Chronic Myelogenous Leukemia – Imatinib and Allogeneic SCT

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Release date: November 30, 2008
Expiration date: November 30, 2009

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Accreditation
This learning activity has been designated for 1.00 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in this activity.

Target Audience
This learning activity is intended for medical oncologists, hematologists, stem cell transplant physicians, and other interested healthcare professionals who manage and treat chronic myelogenous leukemia in the hematology/oncology and transplant patient settings.

Learning Objectives
After completing this educational activity, the learner should be better able to:

  • Discuss the improvement in prognosis for patients with chronic myelogenous leukemia (CML) treated with targeted biologic therapies as compared with older therapeutic interventions
  • Review the key data from the IRIS trial
  • State the criteria for suboptimal response or treatment failure
  • Discuss treatment options available to patients who experience treatment failure while on imatinib

Author
Jorge Cortes, MD
Professor of Medicine & Deputy Chair,
Chief, CML Section
Department of Leukemia
The University of Texas, M. D. Anderson Cancer Center
Houston, Texas

Medical Writers
Karla Badger-Brown, PhD
Toronto, Ontario

Laurel McKee Ranger
Randolph, New Jersey

Disclosure of Financial Interests
As an accredited provider of continuing medical education, Imedex, LLC is required to ask authors to disclose any real or apparent conflict of interest they may have as related to the content of their chapter(s). The existence of commercial or financial interests of speakers related to the subject matter of their chapter(s) should not be construed as implying bias or decreasing the value of their chapter(s). However, the disclosure should help participants form their own judgments.

All authors were independently selected by the organizing committee. Those authors who disclosed affiliations or financial interests with the commercial organizations involved with products, to which they may refer are listed below.
  1. grant research
  2. consultant
  3. speaker's bureau
  4. stock shareholder
  5. other support

Dr Jorge Cortes
Supporters of this activity:
Bristol-Myers Squibb3

Other affiliations:
Novartis3
Wyeth3

Medical Writers
Karla Badger-Brown, PhD
Does not report any affiliations with commercial organizations.

Laurel McKee Ranger
Does not report any affiliations with commercial organizations.

Imedex, LLC Staff Disclosure of Financial Relationships
Imedex, LLC is a subsidiary of AmerisourceBergen Specialty Group, which is a subsidiary of AmerisourceBergen Company. All Imedex staff members, except for the following, who are in a position to control the content of this activity, have no financial relationships with any commercial interests that are relevant to this activity:

Keith Steward, MD, MBA, owns shares of Pfizer Inc and Johnson & Johnson, as well as stock options for AmerisourceBergen.

Chris Bolwell owns shares of GlaxoSmithKline and stock options for AmerisourceBergen.

Bradley Bongiovanni, ND, Becky Lynch, RN, Emily Geiger, and Don Harting, MA, ELS own stock options for AmerisourceBergen.

Imedex, LLC is an independent provider of continuing medical education. Imedex, LLC has no proprietary or financial interest in medical or healthcare products over which the FDA has regulatory authority.

Disclosure of Unapproved Uses and Investigational Drugs
This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the US Food and Drug Administration (FDA) and/or other national regulatory agencies in the United States and other countries. Participants in the United States are encouraged to consult the FDA-approved product labeling for any drug or device mentioned in this program before use. Participants from other countries should consult with their respective regulatory authorities.

Statement of Commercial Support
The following company has provided an unrestricted educational grant in support of this activity: Bristol-Myers Squibb





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